STEMCELL Technologies Kenpaullone, Size: 10 mg

Supplier:  STEMCELL Technologies 72782

Kenpaullone is an ATP-competitive inhibitor of glycogen synthase kinase 3β (GSK-3β; Bain et al.; Leclerc et al.; Zaharevitz et al.). It inhibits GSK-3β, Cdk1/cyclin B, Cdk2/cyclin A, Cdk5/p25, and lymphocyte kinase with IC₅₀ values of 0.23, 0.4, 0.68, 0.85, and 0.47 µM, respectively (Bain et al.; Zaharevitz et al.).REPROGRAMMING· Replaces Klf4 in the generation of induced pluripotent stem (iPS) cells from mouse embryonic fibroblasts (MEFs) transduced with Oct4, Sox2, and c-Myc (Lyssiotis et al.). DIFFERENTIATION· Enhances neuronal differentiation in rat and human neural precursor cell cultures (Castelo-Branco et al.; Lange et al.).· Promotes survival of motor neurons derived from mouse embryonic stem (ES) cells and from Amyotrophic Lateral Sclerosis (ALS) patient iPS cells (Yang et al.). CANCER RESEARCH· Inhibits KLF4 expression and self-renewal in breast cancer stem cells in vitro (Yu et al.).

Catalog No. 50-197-5978

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov