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Medchemexpress LLC KG5 | 877874-85-6 | C20H16F3N7OS | 100 MG
Supplier: Medchemexpress LLC HY15198100MG
KG5 is an orally active dual PDGFRβ and B-Raf allosteric inhibitor, also inhibiting Flt3, KIT, and c-Raf. It demonstrates anticancer and antiangiogenic activities.
- Inhibits vascular smooth muscle cells and endothelial cells viability
- Selectively blocks S338 phosphorylation
- Inhibits PDGFRα, PDGFRβ, Flt3, and KIT
- Prevents tumor growth in an orthotopic renal cell carcinoma model
- Completely blocks angiogenesis in mice
- Disrupts angiogenesis during zebrafish embryogenesis
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