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Medchemexpress LLC KG5 | 877874-85-6 | C20H16F3N7OS | 50 MG
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Catalog No. 5000373421
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KG5 is an orally active dual PDGFRβ and B-Raf allosteric inhibitor, also inhibiting Flt3, KIT, and c-Raf. It demonstrates anticancer and antiangiogenic activities, preventing tumor growth and blocking angiogenesis in various models.

  • Inhibits vascular smooth muscle cells (VSMCs) and endothelial cell viability
  • Selectively blocks S338 phosphorylation
  • Inhibits PDGFRα and β, Flt3, and KIT
  • Inhibits phosphorylation of MEK and ERK in endothelial cells
  • Prevents tumor growth in an orthotopic renal cell carcinoma model
  • Completely blocks angiogenesis in mice

Catalog No. 50-003-73421 Supplier Medchemexpress LLC Supplier No. HY1519850MG
May include imposed supplier surcharges.
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KG5 is an orally active dual PDGFRβ and B-Raf allosteric inhibitor, also inhibiting Flt3, KIT, and c-Raf. It demonstrates anticancer and antiangiogenic activities, preventing tumor growth and blocking angiogenesis in various models.

  • Inhibits vascular smooth muscle cells (VSMCs) and endothelial cell viability
  • Selectively blocks S338 phosphorylation
  • Inhibits PDGFRα and β, Flt3, and KIT
  • Inhibits phosphorylation of MEK and ERK in endothelial cells
  • Prevents tumor growth in an orthotopic renal cell carcinoma model
  • Completely blocks angiogenesis in mice

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