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Medchemexpress LLC KHK-IN-1 hydrochloride | 1303470-48-5 | 98.5% | 1 ML
Supplier: Medchemexpress LLC HY12841A10MM/1ML
KHK-IN-1 hydrochloride (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor with an IC50 of 12 nM and F=34%. It inhibits the production of F1P in HepG2 cell lysates with an IC50 of 400 nM. This compound has potential for the study of diabetes and obesity.
- Selective and cell membrane permeable KHK inhibitor
- Inhibits F1P production in HepG2 cell lysates
- Potential for the study of diabetes and obesity
- Stable in human and rat liver microsome preparations
- Does not significantly inhibit cytochrome P450s
- Has reasonable oral bioavailability in rats
- Soluble in DMSO and H2O
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