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Apexbio Technology LLC Ki8751 228559-41-9 5mg
SDP

Catalog No. 5000095653
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Ki8751 (CAS 228559-41-9) is a small molecule inhibitor that selectively targets vascular endothelial growth factor receptor 2 (VEGFR-2) a key mediator of angiogenesis In biochemical assays Ki8751 demonstrates high potency against VEGFR-2 with an IC50 of 0 9 nM and also exhibits inhibitory activity against c-Kit (IC50 40 nM) PDGFR (IC50 67 nM) and FGFR-2 (IC50 170 nM) In human umbilical vein endothelial cells (HUVECs) Ki8751 suppresses cell proliferation in a dose-dependent manner with complete inhibition observed at 1 nM Additionally in metastatic colorectal cancer cell lines Ki8751 induces cellular senescence In vivo it impedes tumor growth in mouse xenograft models of several human cancers This compound is widely used to investigate VEGFR-2-mediated signaling and tumor angiogenesis

Catalog No. 50-000-95653 Supplier Apexbio Technology LLC Supplier No. A18215
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Ki8751 (CAS 228559-41-9) is a small molecule inhibitor that selectively targets vascular endothelial growth factor receptor 2 (VEGFR-2) a key mediator of angiogenesis In biochemical assays Ki8751 demonstrates high potency against VEGFR-2 with an IC50 of 0 9 nM and also exhibits inhibitory activity against c-Kit (IC50 40 nM) PDGFR (IC50 67 nM) and FGFR-2 (IC50 170 nM) In human umbilical vein endothelial cells (HUVECs) Ki8751 suppresses cell proliferation in a dose-dependent manner with complete inhibition observed at 1 nM Additionally in metastatic colorectal cancer cell lines Ki8751 induces cellular senescence In vivo it impedes tumor growth in mouse xenograft models of several human cancers This compound is widely used to investigate VEGFR-2-mediated signaling and tumor angiogenesis

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