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AdipoGen KillerTRAIL Soluble hrec
Supplier: AdipoGen AG40T00013050
Protein. The extracellular domain of human TRAIL aa 95-281 is fused at the N-terminus to a His-tag and a linker peptide. Source E. coli. Endotoxin content <0.01EU/µg purified protein LAL test Lonza. Liquid. In 20mM HEPES, pH 7.4, 150mM NaCl, 0.005% Tween 20, 1% sucrose, 1mM DTT. Binds to human and mouse TRAIL receptors and osteoprotegerin OPG. Purity >98% SDS-PAGE. TNF-related apoptosis-inducing ligand TRAIL Apo2LCD253 TNFSF10 is a type II transmembrane protein of about 34kDa. Like most members of the tumor necrosis factor TNF superfamily of cytokines TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. Active TRAIL forms trimers and specifically binds to five distinct receptors TRAIL-R1 DR4 Apo2CD261 TNFRSF10A, TRAIL-R2 DR5 KILLER TRICK2ATRICK2B CD262 TNFRSF10B, TRAIL-R3 DcR1LIT TRID CD263 TNFRSF10C, TRAIL-R4 DcR2TRUNDD CD264 TNFRSF10D, and osteoprotegerin OPG OCIF TNFRSF11B.
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