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CPC Scientific H-Leu-Pro-Asn-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (trifluoroacetate salt) 10MG
Supplier: CPC Scientific KISS001C
An LRF-amide motif containing fragment of malignant melanoma metastasis suppressor Kiss1. It bound with low nanomolar affinity to the rat and human G protein-coupled receptor GPR54 expressed in Chinese hamster ovary K1 cells and stimulated PIP2 hydrolysis, Ca2+ mobilization, arachidonic acid release, ERK1/2 and p38 MAP kinase phosphorylation, and stress fiber formation but inhibited cell proliferation.ONE-LETTER SEQUENCE: LPNYNWNSFGLRF-NH2MOLECULAR FORMULA: C78H107N21O18MOLECULAR WEIGHT:1626.84STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [374675-18-0], SYNONYMS: Malignant Melanoma Metastasis-Suppressor KiSS-1 (109-121) (human), KiSS-1 (109-121) (human), Metastin (42-54) (human), Kisspeptin-14 (2-14) (human), Kisspeptin-54 (42-54) (human), H-5962, 55-0-17RESEARCH AREA: CancerREFERENCES: M.Kotani et al., J. Biol. Chem., 276, 34631 (2001); R.A.Silvestre et al., J. Endocrinol., 196, 283 (2008)
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