Invitrogen™ Human KIT [V560G], GST Tag Recombinant Protein

Description

Recombinant Protein

KIT receptor tyrosine kinase is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth.

Specifications

• Accession Number: P10721
• Concentration: See Label
• For Use With (Application): Kinase Assay
• Format: Kit
• Formulation: 50 mM tris HCl with 0.1 mM EDTA, 0.1 mM PMSF, 0.25 mM DTT, 10 mM glutathione, 150 mM NaCl, 25% glycerol and no preservative; pH 7.5
• Gene ID (Entrez): 3815
• Molecular Weight (g/mol): 75.1 kDa
• Name: Human KIT [V560G], GST Tag
• Quantity: 10 μg
• Gene Alias: KIT
• Common Name: KIT (V560G Mutant)
• KinaseFamily: PDGFR Kinase Family
• Protein Length: 544-end
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: GST-tag
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Shipping Condition: Dry Ice
• Expression System: Insect cells
• Protein Form: Recombinant, Active, Catalytic, Mutant
• Form: Liquid