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Apexbio Technology LLC KN-92 176708-42-2 200mg
SDP

Catalog No. 5000063174
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KN-92 is a structurally related but inactive analog of the CaMKII inhibitor KN-93 primarily utilized as a negative control compound in investigations of Ca2 /calmodulin-dependent kinase II (CaMKII) function Unlike KN-93 KN-92 does not effectively interfere with the binding of calmodulin (CaM) to the CaMKII enzyme and does not demonstrate substantial inhibition of CaMKII catalytic activity As a molecular control KN-92 allows researchers to distinguish between CaMKII-specific inhibitory effects and potential non-specific cellular influences when employing KN-93 in experimental models KN-93 itself selectively interacts with the CaM-binding region of CaMKII impeding enzyme activity implicated in cellular responses such as calcium-induced calcium release in cardiac cells histamine-stimulated aminopyrine uptake in gastric parietal cells and calcium-dependent induction of HIF-1 in cancer cells

Catalog No. 50-000-63174 Supplier Apexbio Technology LLC Supplier No. A3529200
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KN-92 is a structurally related but inactive analog of the CaMKII inhibitor KN-93 primarily utilized as a negative control compound in investigations of Ca2 /calmodulin-dependent kinase II (CaMKII) function Unlike KN-93 KN-92 does not effectively interfere with the binding of calmodulin (CaM) to the CaMKII enzyme and does not demonstrate substantial inhibition of CaMKII catalytic activity As a molecular control KN-92 allows researchers to distinguish between CaMKII-specific inhibitory effects and potential non-specific cellular influences when employing KN-93 in experimental models KN-93 itself selectively interacts with the CaM-binding region of CaMKII impeding enzyme activity implicated in cellular responses such as calcium-induced calcium release in cardiac cells histamine-stimulated aminopyrine uptake in gastric parietal cells and calcium-dependent induction of HIF-1 in cancer cells

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