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Apexbio Technology LLC KN-93 139298-40-1 25mg
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Supplier:  Apexbio Technology LLC A353225

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KN-93 (CAS 139298-40-1) is a selective inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII) a serine/threonine kinase activated by calcium-bound calmodulin KN-93 inhibits CaMKII enzymatic activity with reported IC50 values of approximately 0 37 0 5 M in vitro and a Ki value of 2 58 M against cardiac CaMKII In NIH 3T3 cells KN-93 (12 M) induces G1 cell-cycle arrest and at higher concentrations (24 M) promotes apoptosis Due to CaMKII s role in neuronal function cardiac signaling immune activation and disease states including Alzheimer s and arrhythmias KN-93 serves as a tool compound for studying CaMKII-mediated processes in biomedical research

Catalog No. 50-000-63175


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