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Medchemexpress LLC KN-93 (phosphate) | 1913269-12-1 | C26H32CIN2O8PS | 100 MG
SDP

Supplier:  Medchemexpress LLC HY15465B100MG

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KN-93 phosphate is a cell-permeable, reversible, and competitive inhibitor of calmodulin-dependent kinase type II (CaMKII) with a Ki of 370 nM. It is intended for research use only and is not sold to patients.

  • Cell cycle arrest: after 2 days of KN-93 treatment, 95% of cells are arrested in G1.
  • Growth inhibition: blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts.
  • H+, K+-ATPase inhibition: inhibits H+, K+-ATPase activity, strongly dissipates the proton gradient formed in gastric membrane vesicles, and reduces the volume of luminal space.
  • Early afterdepolarization prevention: prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations, and prevents the increase in Ca2+-independent CaM kinase activity.

Catalog No. 50-003-76491


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