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Apexbio Technology LLC KNK437 218924-25-5 200mg
Supplier: Apexbio Technology LLC B5848200
KNK437 (CAS 218924-25-5) is a benzylidene lactam small molecule that inhibits stress-induced synthesis of heat shock proteins (HSPs) HSPs function as molecular chaperones with increased expression under cellular stress and involvement in protein folding cancer and cardiovascular disease KNK437 suppresses the induction of various HSPs in human colon carcinoma cells (COLO 320DM) including after heat stress and arsenite exposure thereby preventing the development of thermotolerance in a dose-dependent manner In murine tumor models KNK437 reduces Hsp72 synthesis when administered prior to hyperthermia This compound is widely used to investigate HSP-mediated stress responses and mechanisms of thermotolerance in cancer research
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