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Gibco™ KnockOut™ Serum Replacement Non-distribution product as customer accommodation. Greener Choice Available on GSA/VA Contract for Federal Government customers only.

KnockOut™ Serum Replacement

Manufacturer:  Gibco™ 10828010

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Catalog No. 10-828-010

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This item is not returnable. View return policy



Gibco™ KnockOut™ Serum Replacement (KnockOut™ SR) is a more defined, FBS-free medium supplement that supports the growth of pluripotent stem cells (PSCs) cultured on fibroblast feeder cells. Designed to replace fetal bovine serum (FBS) in existing protocols, this serum replacement has been trusted by many for almost 20 years. Providing the documents required for regulatory review, KnockOut SR reduces your burden in qualifying reagents when transitioning from research applications to clinical applications. If you are interested in only basic research applications, see the Research Use Only version of this product to ensure that you receive the benefits and pricing that fit your needs.

With KnockOut Serum Replacement, you can:
  • Culture feeder-dependent PSCs with confidence
  • Rely on the improved performance of a qualified, FBS-free formulation
  • Enjoy the peace of mind of having a more stable price and supply compared to FBS

    Culture PSCs with confidence
    KnockOut SR has been cited in more than 2000 publications. It has been shown to support feeder-dependent culture of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). It has also been shown to support reprogramming, embryoid body (EB) formation, in vitro differentiation, cryopreservation, ESC derivation, and many other applications.

    Rely on improved performance
    KnockOut SR has more a defined formulation compared to FBS, which contains many undefined and variable components. Unlike most FBS products, each lot is tested for its ability to support PSCs. Because of this, culturing PSCs with KnockOut SR leads to less differentiation and more compact colony morphology compared to FBS.

    Enjoy the peace of mind of having stable price and supply
    KnockOut SR is not affected by the limited supply and fluctuating prices often seen with FBS. This makes it easier to plan your budget and buy what you need, especially since it is more affordable than most FBS products.

    This reagent is classified as a medical device in several countries. If it is not regulated as a medical device in a specific region, it should be used for laboratory use only.

    This product(s) resides on a Fisher Scientific GSA or VA contract. If you are viewing this page as a nonregistered user, the price(s) displayed is List Price. To view your GSA or VA contract pricing, log in using your account number, or become a registered user by contacting one of our Customer Service teams. You can also view your contract price by searching for this item(s) on GSA Advantage. To place an order, contact Fisher Scientific Customer Service.

  • Specifications


    Clinical Research, Translational Research
    6 to 8
    Serum Replacement
    cGMP for medical devices, 21 CFR Part 820 and ISO 13485
    Growth Performance Assay
    Sustainable packaging
    Stem Cells (Embryonic)
    ES Cell-Qualified
    Dry Ice
    18 Months
    Safety and Handling

    Safety and Handling

    Product Certifications
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