ABclonal Technology KO Validated Lamin A/C Mouse

Supplier:  ABclonal Technology A2687620UL

The protein encoded by this gene is part of the nuclear lamina a two-dimensional matrix of proteins located next to the inner nuclear membrane The lamin family of proteins make up the matrix and are highly conserved in evolution During mitosis the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated Lamin proteins are thought to be involved in nuclear stability chromatin structure and gene expression Vertebrate lamins consist of two types A and B Alternative splicing results in multiple transcript variants Mutations in this gene lead to several diseases Emery-Dreifuss muscular dystrophy familial partial lipodystrophy limb girdle muscular dystrophy dilated cardiomyopathy Charcot-Marie-Tooth disease and Hutchinson-Gilford progeria syndrome

Catalog No. 50-000-08437