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ABclonal Technology KO Validated Rab12 MJFF-A-6E6
Supplier: ABclonal Technology A26172100UL
Rab12 a member of the RAS oncogene family is crucial for intracellular membrane trafficking This small GTPase protein mediates vesicle transport particularly from recycling endosomes to lysosomes playing a key role in autophagy and transferrin receptor degradation Rab12 cycles between inactive GDP-bound and active GTP-bound forms recruiting effectors for vesicle formation movement and fusion It is phosphorylated by LRRK2 which it also regulates Rab12 activates LRRK2 leading to increased phosphorylation of Rab10 aiding in lysosomal function Dysregulation of this pathway especially due to pathogenic LRRK2 mutations may contribute to neurodegenerative processes in Parkinson s disease
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