Apexbio Technology LLC kobe2602 454453-49-7 250mg

Supplier:  Apexbio Technology LLC B3587250

Kobe2602 (CAS 454453-49-7) is a small molecule inhibitor identified through computational screening as a modulator of Ras signaling Kobe2602 impedes the interaction between mutant Ras proteins (H-RasG12V) and c-Raf-1 in NIH 3T3 cells with an IC50 of 10 M and exhibits a Ki of 149 M for Ras inhibition At concentrations of 20 M kobe2602 suppresses the phosphorylation of downstream kinases MEK and ERK In NIH 3T3 cells expressing H-rasG12V it inhibits colony formation with an IC50 of 1 4 M The compound demonstrates growth-inhibitory effects across multiple cancer cell lines harboring activated Ras and in mouse xenograft models administration of 80 mg/kg results in 40 50% tumor growth inhibition Kobe2602 serves as a valuable tool for studying Ras-dependent signaling and oncogenesis

Catalog No. 50-000-92273