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Medchemexpress LLC KPLH1130 | 906669-07-6 | 99.9% | 1 ML
Supplier: Medchemexpress LLC HY12857810MM/1ML
KPLH1130 is a pyruvate dehydrogenase kinase (PDK) inhibitor. It inhibits M1 macrophage polarization by decreasing pro-inflammatory cytokines and reducing M1 phenotype markers. It prevents the decrease in mitochondrial oxygen consumption rate caused by inflammatory stimuli and improves glucose tolerance in mice fed a high-fat diet. This compound is useful for studying obesity-associated metabolic disorders and inflammatory conditions.
- Inhibits M1 macrophage polarization
- Decreases expression of pro-inflammatory cytokines
- Reduces M1 phenotype markers (HIF-1α, iNOS)
- Lowers nitric oxide (NO) production
- Prevents decrease in mitochondrial oxygen consumption rate (OCR) induced by inflammatory stimuli
- Improves glucose tolerance in high-fat diet-fed mice
- Useful for studying obesity-associated metabolic disorders
- Useful for studying inflammatory conditions
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