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Apexbio Technology LLC KPT-330 1393477-72-9 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B14645.1
KPT-330 (CAS 1393477-72-9) is an orally bioavailable small-molecule inhibitor selectively targeting chromosome region maintenance 1 protein (CRM1) a nuclear export receptor involved in the active transport of tumor suppressors transcription factors and cell-cycle regulators Overexpression and deregulation of CRM1 are frequently associated with cancer progression KPT-330 inhibits CRM1 function promoting nuclear retention of regulatory proteins such as p21 and inducing apoptosis through activation of apoptotic signaling pathways (e g PAR-4 activation Bax upregulation PARP cleavage caspase-3 activation) In preclinical studies KPT-330 demonstrated antitumor activity against renal cell carcinoma non-small cell lung cancer and pancreatic cancer models
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