AURORA BIOLABS LLC Kras G12A Nucleotide Exchange Assay Kit, 384 rxn

Supplier:  AURORA BIOLABS LLC 5727412ANK384

KRAS is a member of the RAS protein family, a group of small GTPases involved in cell signaling pathways that regulate cell growth, proliferation, differentiation, and survival. KRAS functions as a molecular switch by cycling between an inactive GDP-bound state and an active GTP-bound state. Activation of KRAS triggers downstream signaling pathways that promote normal cellular functions. Mutations in KRAS, such as the G12A mutation, impair its GTPase activity and lock the protein in the active GTP-bound form, resulting in continuous signaling that drives uncontrolled cell proliferation and cancer development. KRAS mutations are frequently found in pancreatic, colorectal, and lung cancers. The KRAS G12A nucleotide exchange assay is a TR-FRET–based assay designed to measure GTP binding activity and evaluate inhibitors targeting KRAS G12A-mediated signaling pathways.

Catalog No. NC4007596