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Medchemexpress LLC KRAS G12D inhibitor 14 | 2765254-39-3 | 98.9% | 420.45 g·mol⁻¹ | C20H19F3N4OS | 5 MG
SDP

Catalog No. 5000221194
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KRAS G12D inhibitor 14 is a small-molecule research inhibitor that selectively targets the KRAS G12D mutant. It binds KRAS G12D with a reported Kd of 33 nM, shows antiproliferative activity (IC50 = 2.1 μM) in KRAS G12D-mutant cell lines, and reduces KRAS G12D-GTP levels and downstream Raf/ERK signaling. In vivo studies report antitumor efficacy without apparent toxicity.

  • Selective binder of KRAS G12D (Kd = 33 nM).
  • Antiproliferative activity in KRAS G12D cell lines (IC50 = 2.1 μM).
  • Reduces KRAS G12D-GTP and down-regulates phosphorylated Raf and Erk.
  • Induces apoptosis in responsive cancer cell lines.
  • Available as solid and as a 10 mM solution in DMSO for research use.

Catalog No. 50-002-21194 Supplier Medchemexpress LLC Supplier No. HY1446615MG
May include imposed supplier surcharges.
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KRAS G12D inhibitor 14 is a small-molecule research inhibitor that selectively targets the KRAS G12D mutant. It binds KRAS G12D with a reported Kd of 33 nM, shows antiproliferative activity (IC50 = 2.1 μM) in KRAS G12D-mutant cell lines, and reduces KRAS G12D-GTP levels and downstream Raf/ERK signaling. In vivo studies report antitumor efficacy without apparent toxicity.

  • Selective binder of KRAS G12D (Kd = 33 nM).
  • Antiproliferative activity in KRAS G12D cell lines (IC50 = 2.1 μM).
  • Reduces KRAS G12D-GTP and down-regulates phosphorylated Raf and Erk.
  • Induces apoptosis in responsive cancer cell lines.
  • Available as solid and as a 10 mM solution in DMSO for research use.

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