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Medchemexpress LLC KRas G12R inhibitor 1 | C39H38ClF7N6O9 | 1 MG
Supplier: Medchemexpress LLC HY1515231MG
KRas G12R inhibitor 1 is a covalent inhibitor that specifically targets the oncogenic mutant KRas G12R. It functions by exploiting the strong nucleophilicity of the mutant cysteine and irreversibly binding in the Switch II region of KRas, due to its α,β-diketoamide structure. This product can be used in research for K-Ras (G12R)-driven cancers, such as pancreatic ductal adenocarcinoma (PDAC).
- Covalent inhibitor targeting KRas G12R mutant
- Selectivity for the mutant arginine
- Irreversibly binds in the Switch II region of KRas
- Possesses an α,β-diketoamide structure
- Potential for research in K-Ras (G12R)-driven cancers like pancreatic ductal adenocarcinoma (PDAC)
- Purity: 98.40%
- Appearance: Solid, white to off-white
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