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Medchemexpress LLC KRCA-0008 | 1472795-20-2 | 96.2% | 609.12 | 5 MG
Supplier: Medchemexpress LLC 5MGHY12331
KRCA-0008 is a selective ALK/Ack1 inhibitor that can be used for cancer research. It demonstrates high potency against ALK (wt), ALK L1196 M, ALK C1156Y, ALK F1174L, ALK R1275Q, and insulin receptor. This compound is known to inhibit ALK-dependent signaling pathways more potently than crizotinib, induce cell apoptosis, and affect the cell cycle.
- Selective ALK/Ack1 inhibitor with IC50 values of 12 nM for ALK and 4 nM for Ack1.
- Potent against various ALK mutations and insulin receptor.
- Inhibits ALK-dependent signaling pathways.
- Induces cell apoptosis and affects the cell cycle.
- Suppresses tumor growth in an ALK-positive Karpas-299 xenograft model in vivo.
- Useful for cancer research applications.
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