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Medchemexpress LLC KRN2 bromide | 1390654-28-0 | 98.8% | 524.38 | 25 MG
SDP

Catalog No. 5000439833
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KRN2 bromide is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 0.1 μM. It selectively suppresses the expression of pro-inflammatory genes, including Nos2 and Il6. It also dose-dependently inhibits NF-κB p65 binding to Nfat5 promoter 1 and directly blocks the interaction between NF-κB p65 and its DNA binding sequence.

  • Selectively inhibits nuclear factor of activated T cells (NFAT5).
  • Suppresses expression of pro-inflammatory genes.
  • Inhibits NF-κB p65 binding to Nfat5 promoter.
  • Effectively suppresses AIA and CIA in mice, decreasing pro-inflammatory cytokines and autoantibodies.

Catalog No. 50-004-39833 Supplier Medchemexpress LLC Supplier No. 25MGHY112125A
May include imposed supplier surcharges.
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KRN2 bromide is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 0.1 μM. It selectively suppresses the expression of pro-inflammatory genes, including Nos2 and Il6. It also dose-dependently inhibits NF-κB p65 binding to Nfat5 promoter 1 and directly blocks the interaction between NF-κB p65 and its DNA binding sequence.

  • Selectively inhibits nuclear factor of activated T cells (NFAT5).
  • Suppresses expression of pro-inflammatory genes.
  • Inhibits NF-κB p65 binding to Nfat5 promoter.
  • Effectively suppresses AIA and CIA in mice, decreasing pro-inflammatory cytokines and autoantibodies.

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