Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC KRN2 bromide | 1390654-28-0 | 98.8% | 524.38 | 25 MG
Supplier: Medchemexpress LLC 25MGHY112125A
KRN2 bromide is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 0.1 μM. It selectively suppresses the expression of pro-inflammatory genes, including Nos2 and Il6. It also dose-dependently inhibits NF-κB p65 binding to Nfat5 promoter 1 and directly blocks the interaction between NF-κB p65 and its DNA binding sequence.
- Selectively inhibits nuclear factor of activated T cells (NFAT5).
- Suppresses expression of pro-inflammatory genes.
- Inhibits NF-κB p65 binding to Nfat5 promoter.
- Effectively suppresses AIA and CIA in mice, decreasing pro-inflammatory cytokines and autoantibodies.
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?