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Medchemexpress LLC KS-133 (TFA) | 98.95% | 1672.93 | 1 MG
SDP

Catalog No. 5000397084
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KS-133 TFA is a highly selective and potent antagonist of the vascular active enteropeptide receptor 2 (VIPR2). It reverses the tumor-promoting M2 phenotype of tumor-associated macrophages to the anti-tumor M1 phenotype, alters the tumor immune microenvironment, and inhibits tumor growth. It is suitable for research on schizophrenia and cancer immune regulation.

  • Highly selective and potent VIPR2 antagonist
  • IC50 values for Ca influx measurement: 24.8 nM; cAMP measurement: 500 nM
  • Reverses M2 to M1 macrophage phenotype
  • Alters tumor immune microenvironment and inhibits tumor growth
  • Inhibits excessive VIPR2 activation, preventing cognitive impairments and neuronal damage
  • Demonstrates anti-tumor activity and synergistic effects with anti-PD-1 antibodies

Catalog No. 50-003-97084 Supplier Medchemexpress LLC Supplier No. HYP6292A1MG
May include imposed supplier surcharges.
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KS-133 TFA is a highly selective and potent antagonist of the vascular active enteropeptide receptor 2 (VIPR2). It reverses the tumor-promoting M2 phenotype of tumor-associated macrophages to the anti-tumor M1 phenotype, alters the tumor immune microenvironment, and inhibits tumor growth. It is suitable for research on schizophrenia and cancer immune regulation.

  • Highly selective and potent VIPR2 antagonist
  • IC50 values for Ca influx measurement: 24.8 nM; cAMP measurement: 500 nM
  • Reverses M2 to M1 macrophage phenotype
  • Alters tumor immune microenvironment and inhibits tumor growth
  • Inhibits excessive VIPR2 activation, preventing cognitive impairments and neuronal damage
  • Demonstrates anti-tumor activity and synergistic effects with anti-PD-1 antibodies

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