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Medchemexpress LLC KTC1101 | 2764833-47-6 | 98.1% | 476.48 | 100 MG
SDP

Catalog No. 5000392293
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KTC1101 is an orally active pan-PI3K inhibitor that inhibits the PI3K signaling pathway, reducing downstream AKT and mTOR phosphorylation, and decreases Ki67 expression. Its anti-tumor effect stems from a dual mechanism: directly inhibiting tumor cell growth and dynamically enhancing immune response.

  • Induces G1 phase cell cycle arrest in various cell lines (0.1-50000 nM, 48 h).
  • Shows anti-proliferative activity (IC50 20-130 nM) without significant apoptosis.
  • Inhibits all PI3K isoforms (IC50s: PI3Kα 3.72 nM, PI3Kβ 36.29 nM, PI3Kδ 1.22 nM, PI3Kγ 17.09 nM).
  • Reduces AKT and mTOR phosphorylation in WB experiments (0-125 nM, 48 h).
  • Arrests tumor growth in mice xenografts (0-125 mg/kg/day for 14 days, p.o.) without recurrence.

Catalog No. 50-003-92293 Supplier Medchemexpress LLC Supplier No. HY162382100MG
May include imposed supplier surcharges.
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KTC1101 is an orally active pan-PI3K inhibitor that inhibits the PI3K signaling pathway, reducing downstream AKT and mTOR phosphorylation, and decreases Ki67 expression. Its anti-tumor effect stems from a dual mechanism: directly inhibiting tumor cell growth and dynamically enhancing immune response.

  • Induces G1 phase cell cycle arrest in various cell lines (0.1-50000 nM, 48 h).
  • Shows anti-proliferative activity (IC50 20-130 nM) without significant apoptosis.
  • Inhibits all PI3K isoforms (IC50s: PI3Kα 3.72 nM, PI3Kβ 36.29 nM, PI3Kδ 1.22 nM, PI3Kγ 17.09 nM).
  • Reduces AKT and mTOR phosphorylation in WB experiments (0-125 nM, 48 h).
  • Arrests tumor growth in mice xenografts (0-125 mg/kg/day for 14 days, p.o.) without recurrence.

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