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STEMCELL Technologies Ku-0063794, Size: 5 mg
SDP

Supplier:  STEMCELL Technologies 73232

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Ku-0063794 is a cell-permeable, selective inhibitor of the serine-threonine kinase mammalian target of rapamycin (mTOR), inhibiting both the mTORC1 and mTORC2 complexes (IC₅₀ = 10 nM). It shows good specificity (> 1000-fold) against 76 other protein kinases or 7 lipid kinases, including PI3 kinases (García-Martínez et al.).MAINTENANCE· Extends the lifespan of Toll-like receptor (TLR)-activated dendritic cells by preserving mitochondrial oxidative phosphorylation (Amiel et al.).CANCER RESEARCH· Inhibits cell growth by inducing G1-cell cycle arrest in mouse embryonic fibroblasts and human non-small cell lung carcinoma cell lines (García-Martínez et al.; Fei et al.). · Inhibits tumor growth in a xenograft model of renal cell carcinoma (Zhang et al.).· Reduces keloid (fibroproliferative dermal lesion) volume in an ex vivo keloid organ culture model, and inhibits keloid cell spreading, proliferation, migration, and invasive properties in vitro (Syed et al.).

Catalog No. 50-197-6043


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