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Apexbio Technology LLC KU 55933 587871-26-9 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC A46055.1

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KU 55933 (CAS 587871-26-9) is a selective inhibitor of ATM kinase with an IC50 of 13 nM ATM kinase promotes insulin-induced Akt activation via phosphorylation of Akt at Ser473 KU 55933 inhibition of ATM significantly reduces Akt Ser473 phosphorylation in insulin- or IGF-I-treated MDA-MB-453 and PC-3 cells resulting in suppressed proliferation cell cycle arrest at G1 phase and decreased cyclin D1 levels KU 55933 serves as a tool for studying ATM-related signaling and Akt-driven cancer cell growth regulation

Catalog No. 50-000-61637


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