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Medchemexpress LLC KU-57788 | 503468-95-9 | 100.0% | 413.49 | 1 ML
SDP

Catalog No. 502028806
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KU-57788 (NU7441) is a highly potent and selective DNA-PK inhibitor with an IC50 of 14 nM. It acts as an NHEJ pathway inhibitor, and also inhibits PI3K and mTOR with IC50s of 5.0 μM and 1.7 μM, respectively.

  • Highly potent and selective DNA-PK inhibitor (IC50 of 14 nM)
  • NHEJ pathway inhibitor
  • Inhibits PI3K (IC50 of 5.0 μM) and mTOR (IC50 of 1.7 μM)
  • Inhibits the growth of liver cancer HepG2 cells dose- and time-dependently
  • Reduces pDNA-PKcs (S2056) protein expression in liver cancer cells
  • Affects DNA damage repair when double treated with 60Coγ IR
  • Reduces the frequency of NHEJ and increases the rate of HDR following Cas9-mediated DNA cleavage

Catalog No. 50-202-8806 Supplier Medchemexpress LLC Supplier No. HY1100610MG
May include imposed supplier surcharges.
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KU-57788 (NU7441) is a highly potent and selective DNA-PK inhibitor with an IC50 of 14 nM. It acts as an NHEJ pathway inhibitor, and also inhibits PI3K and mTOR with IC50s of 5.0 μM and 1.7 μM, respectively.

  • Highly potent and selective DNA-PK inhibitor (IC50 of 14 nM)
  • NHEJ pathway inhibitor
  • Inhibits PI3K (IC50 of 5.0 μM) and mTOR (IC50 of 1.7 μM)
  • Inhibits the growth of liver cancer HepG2 cells dose- and time-dependently
  • Reduces pDNA-PKcs (S2056) protein expression in liver cancer cells
  • Affects DNA damage repair when double treated with 60Coγ IR
  • Reduces the frequency of NHEJ and increases the rate of HDR following Cas9-mediated DNA cleavage

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