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Medchemexpress LLC KU-57788 | 503468-95-9 | 100.0% | 413.49 | 1 ML
Supplier: Medchemexpress LLC HY1100610MG
KU-57788 (NU7441) is a highly potent and selective DNA-PK inhibitor with an IC50 of 14 nM. It acts as an NHEJ pathway inhibitor, and also inhibits PI3K and mTOR with IC50s of 5.0 μM and 1.7 μM, respectively.
- Highly potent and selective DNA-PK inhibitor (IC50 of 14 nM)
- NHEJ pathway inhibitor
- Inhibits PI3K (IC50 of 5.0 μM) and mTOR (IC50 of 1.7 μM)
- Inhibits the growth of liver cancer HepG2 cells dose- and time-dependently
- Reduces pDNA-PKcs (S2056) protein expression in liver cancer cells
- Affects DNA damage repair when double treated with 60Coγ IR
- Reduces the frequency of NHEJ and increases the rate of HDR following Cas9-mediated DNA cleavage
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