Medchemexpress LLC Kukoamine B | 164991-67-7 | 5 MG

Supplier:  Medchemexpress LLC HYN23935MG

Kukoamine B is a spermine alkaloid and a potent dual LPS and CpG DNA inhibitor. It exhibits anti-inflammatory, anti-diabetic, anti-oxidant, anti-osteoporotic, and neuroprotective effects, and is being studied for its potential in sepsis treatment.

• Increases cell viability and prevents plasma membrane damage in SH-SY5Y cells.
• Attenuates H2O2-induced apoptosis and mitochondrial membrane potential (MMP) loss.
• Demonstrates anti-oxidative stress effects by modulating MAPKs and PI3K-AKT signaling pathways.
• Increases osteoblast differentiation and mineralized nodule formation.
• Dual inhibitor of LPS- and CpG DNA-induced TNF-α and IL-6 release.
• Reduces inflammation and blood glucose.
• Exhibits anti-osteoporotic effects.
• Protects against E. coli challenges and reduces circulatory levels of LPS and TNF-α.

Catalog No. 50-004-20687