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Medchemexpress LLC KVA-D-88 | 2410550-31-9 | 99.81% | 382.19 | 25 MG
Supplier: Medchemexpress LLC 25MGHY139178
KVA-D-88 is a blood-brain barrier-permeable PDE4 inhibitor with IC50 values of 140 nM for PDE4B and 880 nM for PDE4D. It inhibits cocaine-induced hyperlocomotor activity and sensitization by selectively inhibiting PDE4B and reducing cAMP degradation, thereby modulating neuroadaptive responses. This compound can be utilized in the study of cocaine addiction.
- Blood-brain barrier-permeable PDE4 inhibitor
- Selectively inhibits PDE4B and reduces cAMP degradation
- Modulates neuroadaptive responses
- Inhibits cocaine-induced hyperlocomotor activity and sensitization
- Useful in the study of cocaine addiction
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