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Medchemexpress LLC KW-2449 | 1000669-72-6 | 99.9% | 332.40 | 10 MG
Supplier: Medchemexpress LLC 10MGHY10339
KW-2449 is a multi-targeted kinase inhibitor that targets FLT3, ABL, ABLT315I, and Aurora kinase with IC50 values of 6.6, 14, 4, and 48 nM, respectively. It is intended for research use only.
- Targets FLT3, ABL, ABLT315I, and Aurora kinase.
- Exhibits antiproliferative activity against imatinib-resistant K562 cells.
- Inhibits FLT3-mediated STAT5 phosphorylation.
- Increases G1 phase cells and promotes apoptosis.
- Suppresses tumor growth in FLT3-mutated xenograft models.
- Helps release imatinib resistance.
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