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Apexbio Technology LLC KY 02111 1118807-13-8 200mg
Supplier: Apexbio Technology LLC A8213200
KY 02111 (CAS 1118807-13-8) is a selective inhibitor of the Wnt signaling pathway acting downstream of GSK3 and APC within the -catenin destruction complex By modulating canonical Wnt signaling KY 02111 has been shown to significantly reduce luciferase reporter activity in IMR90-1 human induced pluripotent stem cells (hiPSCs) transfected with a TCF-responsive plasmid in a dose-dependent manner When applied to differentiating cardiac cell colonies KY 02111 induces the expression of cardiac-specific markers in approximately 73 85% of IMR90-1 hiPSCs by day 30 This compound is valuable for investigating Wnt-mediated cellular processes and optimizing protocols for directed differentiation of pluripotent stem cells
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