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Medchemexpress LLC L-2-hydroxyglutaric acid | 13095-48-2 | 95.1% | 148.11 | 10 MG
Supplier: Medchemexpress LLC HY11303910MG
L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. It can inhibit histone demethylases, thereby promoting histone methylation. L-2-Hydroxyglutaric acid also inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki values of 2.52 mM and 11.13 mM, respectively. It is potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs) including the Ten Eleven Translocation (TET) enzymes.
- Epigenetic modifier
- Putative oncometabolite in renal cancer
- Inhibits histone demethylases
- Inhibits mitochondrial creatine kinase (Mi-CK) activity
- Potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs)
- Human endogenous metabolite
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