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Medchemexpress LLC L-368,899 hydrochloride | 160312-62-9 | 99.9% | 591.23 | 25 MG
Supplier: Medchemexpress LLC 25MGHY108677
L-368,899 hydrochloride is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist. It is used as a tocolytic agent and shows less activity on VP receptors in human and rat liver and kidney.
- Potent, orally bioavailable, non-peptide oxytocin receptor antagonist
- IC50s of 8.9 nM for rat uterus oxytocin receptor
- IC50s of 26 nM for human uterus oxytocin receptor
- Used as a tocolytic agent
- Less active on VP receptor in human and rat liver and kidney
- Exhibits similar pharmacokinetics in rats and dogs
- Orally available with demonstrated bioavailability in rats
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