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Medchemexpress LLC L-371,257 | 162042-44-6 | 99.34 % | 507.58 | 100 MG
Supplier: Medchemexpress LLC HY15010100MG
L-371,257 is an orally bioavailable, non-blood-brain barrier penetrant compound that functions as a selective and competitive antagonist of the oxytocin receptor. It exhibits high affinity for both the oxytocin receptor (Ki=19 nM) and the vasopressin V1a receptor (Ki=3.7 nM).
- Orally bioavailable
- Non-blood-brain barrier penetrant
- Selective and competitive oxytocin receptor antagonist (pA2=8.4)
- High affinity for oxytocin receptor (Ki=19 nM)
- High affinity for vasopressin V1a receptor (Ki=3.7 nM)
- Stimulates weight gain in rat models
- Exhibits activity at human oxytocin receptor in CHO cells (EC50 = 4.6 nM)
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