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Apexbio Technology LLC L-732,138 148451-96-1 50mg
Supplier: Apexbio Technology LLC B647850
L-732 138 (CAS 148451-96-1) is a potent and selective antagonist of the neurokinin-1 (NK-1) receptor exhibiting an IC50 of 2 3 nM Comparative studies demonstrate its affinity for the human NK-1 receptor is approximately 200-fold higher than for the rodent NK-1 receptor and markedly greater than for human NK-2 and NK-3 receptors By inhibiting NK-1 receptor-mediated signaling L-732 138 has been shown to attenuate hyperalgesia and display anti-tumor properties in preclinical models Its receptor selectivity and biological activity make it a valuable tool for investigating NK-1 receptor function and associated pathophysiological processes
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