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Medchemexpress LLC L-733060 hydrochloride | 148687-76-7 | 99.9% | 439.82 | 1 MG
Supplier: Medchemexpress LLC 1MGHY14406A
L-733060 hydrochloride is a selective neurokinin-1 (NK-1) receptor antagonist. It primarily regulates pain transmission and neural plasticity by blocking the binding of Substance P to the NK-1 receptor. It blocks the promoting effect of Substance P on long-term potentiation (LTP) in the hippocampus and reverses orofacial hyperalgesia induced by experimental occlusal interference (EOI) in rats. Additionally, it inhibits neurogenic plasma extravasation and acts as an anti-tumor agent, making it suitable for studying chronic orofacial pain.
- Selective neurokinin-1 (NK-1) receptor antagonist
- Regulates pain transmission and neural plasticity
- Blocks Substance P binding to NK-1 receptor
- Reverses orofacial hyperalgesia
- Inhibits neurogenic plasma extravasation
- Acts as an anti-tumor agent
- Suitable for studying chronic orofacial pain
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