Cayman Chemical L-745 870hydrochlorIde 100mg

Supplier:  Cayman Chemical 37586100 MG

A dopamine D4 receptor antagonist (Ki = 0.43 nM); selective for dopamine D4 receptors over dopamine D2 and D3 receptors (Kis = 960 and 2,300 nM, respectively); selective for dopamine D4 receptors over α2A-, α2B-, and α2C-adrenergic receptors (IC50s = 0.00043, 0.16, 0.17, and 0.23 µM, respectively) and 5-HT2C and 5-HT1A receptors (IC50s = 0.2 and 2.9 µM, respectively); inhibits dopamine-induced inhibition of forskolin-induced cAMP production in HEK293 cells expressing human dopamine D4 receptors at 100 nM; inhibits mescaline-induced head twitches in mice at 3, 10, and 30 mg/kg

Catalog No. 50-291-8154