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Medchemexpress LLC L-745870 hydrochloride | 1173023-36-3 | 99.91% | C18H20Cl2N4 | 1 ML
Supplier: Medchemexpress LLC HY14325B10MM/1ML
L-745870 hydrochloride is a potent, selective, brain-penetrant, and orally active dopamine D4 receptor antagonist. It exhibits high affinity for D4 receptors, with weaker affinity for D2 and D3 receptors, and moderate affinity for 5-HT2 receptors, sigma sites, and α-adrenoceptors. This compound demonstrates good pharmacokinetic properties and excellent brain penetration in vivo.
- Potent, selective, brain-penetrant, and orally active dopamine D4 receptor antagonist
- High affinity for D4 receptors (Ki of 0.43 nM)
- Weaker affinity for D2 and D3 receptors
- Moderate affinity for 5-HT2 receptors, sigma sites, and α-adrenoceptors
- Good pharmacokinetic properties with 20-60% oral bioavailability
- Plasma t1/2 of 2.1-2.8 hours in rats and monkeys
- Excellent brain penetration in rats
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