Medchemexpress LLC L-745870 hydrochloride | 1173023-36-3 | 99.91% | C18H20Cl2N4 | 50 MG

Supplier:  Medchemexpress LLC HY14325B50MG

L-745870 hydrochloride is a potent, selective, brain-penetrant, and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. It demonstrates weaker affinity for D2 and D3 receptors, and moderate affinity for 5-HT2 receptors, sigma sites, and α-adrenoceptors. This compound is valuable for research into dopamine receptor functions and potential therapeutic applications.

• Potent, selective, and orally active dopamine D4 receptor antagonist.
• Exhibits weaker affinity for D2 and D3 receptors.
• Good brain penetration and oral bioavailability in animal models.
• Antagonizes D4 receptor inhibition of agonist-induced [35S]-GTPγS binding.
• Blocks dopamine-induced inhibition of Ca2+ currents in GH4C1 cells.
• Inhibits D4 activation of G protein-coupled inwardly rectifying K+ channels.

Catalog No. 50-003-56349