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Medchemexpress LLC L-778123 hydrochloride | 253863-00-2 | 99.9% | 442.34 | 1 ML
Supplier: Medchemexpress LLC HY16273A10MM/1ML
L-778123 hydrochloride is a dual inhibitor of FPTase and GGPTase-I, with IC50 values of 2 nM and 98 nM respectively. For research use only, not for sale to patients. In vitro, it does not show obvious cytotoxicity on HT-29 and A549 cell lines (IC50: >100 μM) but can generate synergistic effects with Doxorubicin, with decreased IC50s of 1.72 and 1.52 μM respectively. It inhibits myeloid leukemia cell proliferation with IC50 values of 0.2 μM-1.8 μM for cell lines, and 0.1 μM-161.8 μM in primary samples. It inhibits H-RAS prenylation in HL-60 cells, and inhibits phosphorylated MEK-1/2 level. It also inhibits lymphocyte activation and function in human PBMCs.
- Dual inhibitor of FPTase and GGPTase-I
- Shows synergistic effects with Doxorubicin
- Inhibits myeloid leukemia cell proliferation
- Inhibits H-RAS prenylation and phosphorylated MEK-1/2 level
- Inhibits lymphocyte activation and function
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