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Medchemexpress LLC L-778123 hydrochloride | 253863-00-2 | 99.9% | 442.34 | 50 MG
Supplier: Medchemexpress LLC HY16273A50MG
L-778123 hydrochloride is a dual inhibitor of FPTase and GGPTase-I, with IC50 values of 2 nM and 98 nM respectively. It is intended for research use only.
- Dual inhibitor of FPTase and GGPTase-I.
- Exhibits IC50 values of 2 nM for FPTase and 98 nM for GGPTase-I.
- Alone, it does not show obvious cytotoxicity on HT-29 and A549 cell lines (IC50: >100 μM), but can generate synergistic effects with Doxorubicin.
- Inhibits myeloid leukemia cell proliferation with IC50 values ranging from 0.2 μM to 1.8 μM for cell lines, and 0.1 μM to 161.8 μM in primary samples.
- Inhibits H-RAS prenylation in HL-60 cells and phosphorylated MEK-1/2 levels.
- Inhibits lymphocyte activation and function in human PBMCs.
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