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Medchemexpress LLC L-Arginine, N2-(1-oxo-3-phenylpropyl)-L-ornithyl-L-prolyl-3-cyclohexyl-D-alanyl-L-tryptophyl-, (5→1)-lactam | 514814-49-4 | 99.5% | 839.04 | 50 MG
Supplier: Medchemexpress LLC HY11013610MG
PMX 205 is a potent and orally active complement C5a receptor (C5aR; CD88) antagonist. This selective antagonist is extensively used in research for its biological activities and therapeutic potential across various disease models.
- Potent and selective complement C5a receptor (C5aR; CD88) antagonist.
- Orally active for convenience in in vivo studies.
- Demonstrated extended survival and reduced motor decline in neurological disease models.
- Reduced astroglial proliferation in spinal cord.
- Decreased fibrillar plaque load and hyperphosphorylated tau in Alzheimer's disease models.
- Blocked C5a-induced cellular expression changes and proliferation.
- Exhibited suppression of GPX4 expression and inhibition of tumor growth in specific studies.
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