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Medchemexpress LLC L-Arginine, N2-(1-oxo-3-phenylpropyl)-L-ornithyl-L-prolyl-3-cyclohexyl-D-alanyl-L-tryptophyl- | 514814-49-4 | 99.5% | 839.04 | 1 ML
Supplier: Medchemexpress LLC HY1101361MG
PMX 205 is a potent complement C5a receptor (C5aR; CD88) antagonist.
- Recruits and activates microglia and astrocytes in vitro by activating a G protein-coupled cell-surface C5aR.
- Shows significant results in MTT assays at 24 h, 48 h, and 72 h incubation times.
- Orally active, selective C5aR antagonist.
- Extends survival time, reduces end-stage motor scores, and decreases astroglial proliferation in animals.
- Reduces fibrillar plaque load and hyperphosphorylated tau in murine models of Alzheimer's disease.
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