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Medchemexpress LLC L-Arginine, N2-(1-oxo-3-phenylpropyl)-L-ornithyl-L-prolyl-3-cyclohexyl-D-alanyl-L-tryptophyl- | 514814-49-4 | 99.5% | 839.04 | 25 MG
Supplier: Medchemexpress LLC 25MGHY110136
PMX 205 is a potent and orally active complement C5a receptor (C5aR; CD88) antagonist. This selective C5aR antagonist is supplied in solid form as a white to off-white powder.
- Potent complement C5a receptor (C5aR; CD88) antagonist
- Orally active and selective C5aR antagonist
- Showed significant results in MTT assays
- Extended survival time and reduced end-stage motor scores in a rat model of amyotrophic lateral sclerosis
- Reduced astroglial proliferation in SOD1G93A rats
- Reduced fibrillar plaque load in Tg2576 mice
- Reduced hyperphosphorylated tau (69%) in 3xTg mice
- Blocked C5a-stimulated increase in CD44 expression in PECs
- Reversed C5a-increased PEC-derived COL4A2 secretion
- Reduced C5a-increased proliferation of PECs
- Induced suppression of GPX4 expression and inhibition of tumor growth in mice
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