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Medchemexpress LLC L-Asparagine-15N2 monohydrate | 287484-32-6 | MFCD01073515 | 152.12 | 25 MG
Supplier: Medchemexpress LLC 25MGHYN0667S2
L-Asparagine-15N2 monohydrate is the 15N-labeled L-Asparagine monohydrate, an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is an anti-leukemic enzyme that promotes asparagine and glutamine depletion, inhibiting protein biosynthesis in lymphoblasts. Its removal from plasma by L-Asparaginase leads to inhibition of RNA and DNA synthesis and subsequent apoptosis, selectively inhibiting the growth of cancer cells with low asparagine synthetase expression. This compound can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
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