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Medchemexpress LLC L-Aspartic acid, N-(phosphonoacetyl)-, trisodium salt | 70962-66-2 | 98.0% | 321.06 | 10 MG
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Supplier:  Medchemexpress LLC HY112732B10MG

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Sparfosic acid trisodium is a DNA antimetabolite agent and a potent inhibitor of aspartate transcarbamoyl transferase, which catalyzes the second step of de novo pyrimidine biosynthesis. It synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines. It is for research use only and not sold to patients.

  • DNA antimetabolite agent
  • Potent inhibitor of aspartate transcarbamoyl transferase
  • Synergistically enhances the cytotoxicity of 5-FU and IFN against human colon cancer cell lines
  • Treatment with 490 mg/kg in mice bearing B16 melanoma increased life-span by 77% to 86%
  • Lewis lung carcinoma is highly sensitive, with treatment leading to a cure in 50% of mice

Catalog No. 50-004-35737


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