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Sigma Aldrich Fine Chemicals Biosciences L Lactic Dehydrogenase fro

Supplier:  Sigma Aldrich Fine Chemicals Biosciences L125450KU

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Lactic Dehydrogenase (LDH) has a total molecular weight of 140 kDa and is composed of 4 subunits which are designated M subunit (muscle) and H subunit (heart). These subunits may be mixed in any of 5 combinations (M4 M3H1 M2H2 MH3 and H4). Skeletal muscle contains LDH that is predominately M4 with some small amounts of M3H and traces of H2H2. The H and M subunits are quite similar in molecular weight but differ substantially in amino acid composition. Rabbit muscle LDH dissociates into dimeric species (MW ~70 kDa) in acetate-chloride at pH 5.0 the dissociation is reversible. Biochemistry 13 3527-3531 (1974). Oxidizes glyoxylate and lactate.Isoelectric point 8.4-8.6Optimal pH 7.5 .

Catalog No. 50-291-4450


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