Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 501998339

Apexbio Technology LLC L-Mimosine, 250mg CAS# 500-44-7
SDP

Supplier:  Apexbio Technology LLC B4751250

Encompass_Preferred

L-mimosine is a prolyl 4-hydroxylase inhibitor and acts as an iron chelator [1]. In rats, it interfered with the reconstitution of the active human prolyl 4-hydroxylase with an IC50 value of 120 M [2].Prolyl 4-hydroxylase (EC 1.14.11.2) is an 22 tetramer. It catalyses the formation of 4-hydroxyproline in coliagen via the hydroxylation of proline residues in the peptide linkage [3]. Prolyl-4-hydroxylase domain-containing protein (PHD) regulates HIF-1 levels in renal medulla and participates in controlling renal Na+ excretion [4].L-mimosine acted as an inhibitor for prolyl 4-hydroxylase in cultured vascular cells. L-mimosine dose-dependently inhibited the activity of prolyl hydroxylase in rat and human smooth muscle cells (SMC) and at concentrations of 400-500 M decreased hydroxyprolyl generation by 80-90%. Other sizes are also available. Please inqury us for quote.

Catalog No. 50-199-8339


May include imposed supplier surcharges.
Only null left
Add to Cart

Product Content Correction

The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.