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Apexbio Technology LLC L-Mimosine, 250mg CAS# 500-44-7

Supplier: Apexbio Technology LLC B4751250

L-mimosine is a prolyl 4-hydroxylase inhibitor and acts as an iron chelator [1]. In rats, it interfered with the reconstitution of the active human prolyl 4-hydroxylase with an IC50 value of 120 M [2].Prolyl 4-hydroxylase (EC 1.14.11.2) is an 22 tetramer. It catalyses the formation of 4-hydroxyproline in coliagen via the hydroxylation of proline residues in the peptide linkage [3]. Prolyl-4-hydroxylase domain-containing protein (PHD) regulates HIF-1 levels in renal medulla and participates in controlling renal Na+ excretion [4].L-mimosine acted as an inhibitor for prolyl 4-hydroxylase in cultured vascular cells. L-mimosine dose-dependently inhibited the activity of prolyl hydroxylase in rat and human smooth muscle cells (SMC) and at concentrations of 400-500 M decreased hydroxyprolyl generation by 80-90%. Other sizes are also available. Please inqury us for quote.
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