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Apexbio Technology LLC L-NIO dihydrochloride 159190-44-0 10mg
Supplier: Apexbio Technology LLC B634510
L-NIO dihydrochloride (CAS 159190-44-0) is a potent inhibitor of nitric oxide synthase (NOS) targeting inducible (iNOS) endothelial (eNOS) and neuronal (nNOS) isoforms with an IC50 of 65 M By blocking NOS activity L-NIO reduces nitric oxide (NO) production in activated macrophages and neutrophils which can influence both tumor cell cytotoxicity and inflammatory responses In vitro and in vivo studies demonstrate that L-NIO modulates vascular responses preventing immune complex-induced vasculitis and counteracting hypotensive effects triggered by acetylcholine and bradykinin This compound is widely utilized to investigate the role of NO in inflammation vascular regulation and immune-mediated tissue injury
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